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Non sedating antihistamines in children

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Excessive doses in children have led to respiratory depression, coma and death.

Symptomatic measures, such as increasing fluids, making sure children get enough rest and reducing the spread of the virus (including regular hand washing) should be practiced.

"In some studies we reviewed, some people actually experienced more sedation with the newer, nonsedating formulas than with the older, sedating products.

This means it has an effect on small blood vessels, resulting in dilated capillaries (redness), and leakage of protein-rich fluid into surrounding skin (swelling).

Fortunately, the child eventually recovered without any on-going ill-effects.

Sedating antihistamines have the ability to cross the blood-brain barrier, the ability to bind to non-histamine receptors and have less selectivity for peripheral or central H1-receptors.

There are at least two kinds of histamine receptors, hence are mainly H1 blockers.

The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD.

They are valuable drugs to reduce symptoms due to allergic diseases, especially those mediated by histamine.

They do not always completely control the allergic reaction because they do not counteract other chemicals that may be responsible for the symptoms.

Because it is almost impossible to completely avoid exposure to allergens, oral antihistamines continue to serve as the first line pharmacological treatment for allergic rhinitis.

Oral antihistamines available on the market are classified into two groups; first-generation (sedating) and second-generation (non-sedating) antihistamines.